NEWS ABOUT THE CURE

Research Update: Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry

The following study was funded in part by the DIPG/DMG Collaborative and The Cure Starts Now: Background Cross-sectional tumor measures are traditional clinical trial endpoints; however volumetric measures may better assess tumor growth. We determined the correlation and compared the prognostic impact of cross-sectional and volumetric measures of progressive disease (PD) among patients with DIPG. Methods Imaging and clinical data were abstracted from the International DIPG Registry. Tumor volume

Research Update: Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma

The following study was funded in part by the DIPG/DMG Collaborative and The Cure Starts Now: Abstract Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We conducted a multi-site Phase 1 trial of the imipridone ONC201 for children with H3K27M-mutant glioma (NCT03416530). Patients enrolled on Arm D of the trial (n = 24) underwent serial lumbar puncture for cell-free tumor DNA (cf-tDNA) analysis

Research Update: Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant

Background Diffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although GD2-CAR T-cells demonstrated significant anti-tumor activity against DMG H3K27M-mutant in vivo, a multimodal approach may be needed to more effectively treat patients. We investigated GD2 expression in DMG/DIPG and other pediatric high-grade gliomas (pHGG) and sought to identify chemical compounds that would enhance GD2-CAR

Research Update: Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment

In 2019 Dr. Mara Vinci of Bambino Gesu Children's Hospital proposed an study demonstrating using imaging mass cytometry to identify next generation imaging biomarkers in PHGG and DIPG. This project was approved for funding by the The Cure Starts Now and here are the results: Lay Summary of Proposal The field of pediatric neuro-oncology has been greatly advanced by recent studies, which have better outlined the spectrum of pediatric Central Nervous System (CNS) tumors, into more clearly distinct

Research Update: Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

In 2019 Dr. Carl Koschmann of University of Michigan Hospitals proposed an study demonstrating the Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma. This project was approved for funding by the DIPG/DMG Collaborative and The Cure Starts Now and here are the results: Abstract Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous re

Brain Tumor Awareness Month - Go Gray in May

May is "Brain Tumor Awareness Month," a time to recognize and honor those who have been affected by all types of brain cancer while fundraising to support current and ongoing research to make brain cancer a thing of the past. Gray matter is a major component of the central nervous system in the brain, which is part of why the ribbon color for the month of May is gray. This year, The Cure Starts Now invites you to be a ray of hope among all of the gray and take action in the fight against brai

Zips Esports at The University of Akron partners with The Cure Starts Now to “Nerf” Cancer!

Akron, OH | April, 2022 – The University of Akron’s Zips Esports program has partnered with Ohio-based charity, The Cure Starts Now, to host a fundraising event for video gamers to raise money for pediatric brain cancer research. During the 8-hour gaming fundraiser, participating University of Akron students will have the opportunity to play video games throughout the day and fundraise for a crucial cause. The funds raised will benefit pediatric brain cancer research through The Cure Starts Now’

9th Annual Sydney's Band of Gold Golf Tournament Aims to Raise Funds for Pediatric Brain Cancer Research

The North Texas Chapter of The Cure Starts Now has raised over $1.4 million since inception! Grapevine, TX | April 6, 2022 – The North Texas Chapter of The Cure Starts Now is hosting it’s 9th Annual Sydney’s Band of Gold Golf Tournament in honor or Sydney Bjornberg, a little girl who battled DIPG (Diffuse Intrinsic Pontine Glioma), a brain tumor that is highly aggressive and difficult to treat.  The golf outing is being held on April 11, 2022 at the Cowboys Golf Club, the first and only NFL-them

Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry

As a supplement to the Journal of Clinical Oncology 2018 publishing from the International DIPG/DMG Registry and statistics of DIPG and DMG, the International DIPG/DMG Registry releases new age specific findings and long-term survival prognosis. Background Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteris

Social community giant, The Dad, has partnered with The Cure Starts Now to “nerf” cancer!

Cincinnati, OH | February 10, 2022 – The Dad has partnered with The Cure Starts Now as the premier sponsor of “Hearts for Heroes,” a fundraising event for streamers to raise money for pediatric brain cancer research. During Hearts for Heroes, each streamer will be matched with a young Hero who is fighting brain cancer.  The funds raised will benefit cancer research in honor of the Hero.  The Cure Starts Now will compile all donor messages onto hand-written valentines that will be mailed to the H