In the quest to cure cancer, we know that hope alone isn't enough; it is action that moves us forward. It’s families, researchers, and supporters coming together to take bold steps toward curing brain cancer. Because government funding is so uncertain, we are not leaving our children’s futures to chance. No matter what, we are continuing to lead where others hesitate.

This year, that leadership takes a powerful form: 18 groundbreaking grant proposals submitted to our Big Fat Grant (BFG) program, our largest call for funding. Researchers from 16 institutions have come forward with ideas that could radically change how we fight brain cancer, collectively requesting nearly $17 million. The urgency is real, and the potential is extraordinary.

These aren’t just theoretical ideas. Many proposals are ready to begin clinical trials, building on years of foundational work. Others present visionary approaches that target cancer’s toughest forms with smarter, safer methods, from precision immunotherapies to targeted gene therapy and revolutionary radiation techniques.

Among the highlights:

• A diet-based therapy that deprives tumors of nutrients they need to grow, in combination with a cancer drug.
• Immune system training using cutting-edge T-cell therapies that don’t require invasive biopsies, making treatment more accessible.
• RNA nanoparticle vaccines that harness the same principles as modern mRNA COVID vaccines, adapted to fight deadly brain tumors.
• Focused ultrasound and blood-brain barrier breakthroughs that improve drug delivery where it's needed most—directly into tumors.
• And a wave of CAR T-cell innovations, designed not just to attack cancer but to work smarter, last longer, and reach deeper.

Each of these 18 proposals represents hope for the families who have lost their children and for families waiting for their miracle. But none of this work moves forward without funding.
At The Cure Starts Now, we are powered by a global community that refuses to accept the status quo. We fund what others won’t. We prioritize the toughest cancers in the smallest patients, because our kids deserve a fighting chance.

You Can Be Part of the Cure

This moment calls for bold generosity. If you've ever asked what you can do to help fight childhood cancer, this is it. Your donation directly fuels clinical trials, novel therapies, and scientific breakthroughs. Every dollar brings us closer to answers, to cures, and to hope fulfilled. We’re not waiting. We’re funding the future. https://donate2csn.org